Pseudomonas aeruginosa is a versatile Gram-negative bacterium that grows in soil, coastal marine habitats, and on plant and animal tissues. People with cystic fibrosis, burn victims, and other patients in intensive care units are particularly at risk of disease resulting from P. aeruginosa infection. The complete sequence of the genome of P. aeruginosa strain PAO1 was published in Nature in the year 2000 and was noted for its large size and diverse metabolic capacity. The genome annotation is now being continually updated and the database functionality is being expanded to facilitate accelerated discovery of P. aeruginosa drug targets and vaccine candidates. This effort is being co-ordinated by Dr. Fiona Brinkman at Simon Fraser University and Dr. Bob Hancock at the University of British Columbia with database development led by Geoff Winsor of the Brinkman group. Funding for this work is gratefully provided by Cystic Fibrosis Foundation Therapeutics Inc., a non-profit drug discovery and development affiliate of the Cystic Fibrosis Foundation. The current annotation is updated using recent research literature and peer-reviewed submissions by a worldwide community of PseudoCAP participating researchers. If you are interested in participating, we invite you to get involved. Note that as of 2005, this database now also provides data on other Pseudomonas species genomes, which acts as a valuable comparative resource for P. aeruginosa research, as well as being useful for the larger Pseudomonas research community. We aim to continue to provide a central portal through which researchers may access high quality genome-associated information about P. aeruginosa and potential drug/vaccine targets, helping to accelerate research efforts to control important Pseudomonas infections.