Pseudomonas aeruginosa PAO1, PA0223 (ergB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0223
Name
ergB
Replicon chromosome
Genomic location 252913 - 253794 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_248914.1
GI 15595420
Affymetrix PA0223_at
DNASU PaCD00006099
Entrez 878110
GenBank AAG03612.1
INSDC AAG03612.1
NCBI Locus Tag PA0223
protein_id(GenBank) gb|AAG03612.1|AE004460_5|gnl|PseudoCAP|PA0223
TIGR NTL03PA00224
UniParc UPI00000C4FA6
UniProtKB Acc Q9I6R5
UniProtKB ID Q9I6R5_PSEAE
UniRef100 UniRef100_W0YJN3
UniRef50 UniRef50_A0A0A1FXC1
UniRef90 UniRef90_B7V2D6

Product

Feature Type CDS
Coding Frame 1
Product Name
ErgB
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -5.89
Kyte-Doolittle Hydrophobicity Value 0.147
Molecular Weight (kDa) 31.7
Isoelectric Point (pI) 5.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3NA8 LYASE 06/01/10 Crystal Structure of a putative dihydrodipicolinate synthetase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.85 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 633 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000222 (1144 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0223
Search term: ergB
Search term: ErgB

Human Homologs

References

Species-specific recruitment of transcription factors dictates toxin expression.
Trouillon J, Sentausa E, Ragno M, Robert-Genthon M, Lory S, Attrée I, Elsen S
Nucleic Acids Res 2020 Mar 18;48(5):2388-2400
PubMed ID: 31925438