Pseudomonas aeruginosa UCBPP-PA14, PA14_02310 (atsA)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_02310
Name	atsA
Replicon	chromosome
Genomic location	206784 - 208394 (- strand)
Transposon Mutants	2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	YP_788341.1
GI	116053904
Entrez	4383583
INSDC	ABJ15140.1
NCBI Locus Tag	PA14_02310
UniParc	UPI000045D3A8
UniProtKB Acc	Q02UP5
UniProtKB ID	Q02UP5_PSEAB
UniRef100	UniRef100_Q02UP5
UniRef50	UniRef50_P51691
UniRef90	UniRef90_P51691

Product

Feature Type	CDS
Coding Frame	1
Product Name	arylsulfatase
Synonyms
Evidence for Translation
Charge (pH 7)	-12.15
Kyte-Doolittle Hydrophobicity Value	-0.365
Molecular Weight (kDa)	59.8
Isoelectric Point (pI)	5.62

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1HDH	HYDROLASE	11/16/00	Arylsulfatase from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.3	X-RAY DIFFRACTION	98.9
4CXU	HYDROLASE	04/08/14	G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with 3-Br-Phenolphenylphosphonate	PSEUDOMONAS AERUGINOSA	2.03	X-RAY DIFFRACTION	97.8
4CYS	HYDROLASE	04/14/14	G6 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with Phenylphosphonic acid	PSEUDOMONAS AERUGINOSA	1.88	X-RAY DIFFRACTION	97.8
5AJ9	HYDROLASE	02/20/15	G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa	PSEUDOMONAS AERUGINOSA	2	X-RAY DIFFRACTION	97.6
4CYR	HYDROLASE	04/14/14	G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa	PSEUDOMONAS AERUGINOSA	1.72	X-RAY DIFFRACTION	97.8
4CXK	HYDROLASE	04/07/14	G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa	PSEUDOMONAS AERUGINOSA	1.86	X-RAY DIFFRACTION	97.2
4CXS	HYDROLASE	04/08/14	G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid	PSEUDOMONAS AERUGINOSA	2.3	X-RAY DIFFRACTION	97.8

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 241 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000181 (366 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_02310 Search term: atsA Search term: arylsulfatase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000456339 arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] E-value: 3.4e-30 Percent Identity: 29.8
Ensembl 110, assembly GRCh38.p14	ENSP00000264914 arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] E-value: 3.4e-30 Percent Identity: 29.8
Ensembl 110, assembly GRCh38.p14	ENSP00000379455 arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] E-value: 3.4e-30 Percent Identity: 29.8

References