Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_45960
|
Name |
lasR
|
Replicon | chromosome |
Genomic location | 4085339 - 4086058 (- strand) |
Transposon Mutants in orthologs | 8 transposon mutants in orthologs |
RefSeq | YP_791822.1 |
GI | 116049375 |
Entrez | 4382864 |
INSDC | ABJ10611.1 |
NCBI Locus Tag | PA14_45960 |
UniParc | UPI000012E231 |
UniProtKB Acc | Q02JR4 |
UniProtKB ID | Q02JR4_PSEAB |
UniRef100 | UniRef100_P25084 |
UniRef50 | UniRef50_P25084 |
UniRef90 | UniRef90_P25084 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
transcriptional regulator LasR
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -1.68 |
Kyte-Doolittle Hydrophobicity Value | -0.020 |
Molecular Weight (kDa) | 26.6 |
Isoelectric Point (pI) | 6.51 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3JPU | TRANSCRIPTION | 09/04/09 | LasR-TP4 complex | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 100.0 |
2UV0 | TRANSCRIPTION | 03/08/07 | Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer | PSEUDOMONAS AERUGINOSA | 1.8 | X-RAY DIFFRACTION | 100.0 |
6MWZ | TRANSCRIPTION | 10/30/18 | LasR LBD T75V/Y93F/A127W:BB0126 | Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas aeruginosa UCBPP-PA14 | 1.657 | X-RAY DIFFRACTION | 98.7 |
6MVN | TRANSCRIPTION | 10/26/18 | LasR LBD L130F:3OC10HSL complex | Pseudomonas aeruginosa (strain UCBPP-PA14) | 2.2 | X-RAY DIFFRACTION | 99.6 |
6V7X | DNA BINDING PROTEIN/Viral protein | 12/09/19 | Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR | Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3 | 2.9 | X-RAY DIFFRACTION | 100.0 |
6MWH | TRANSCRIPTION | 10/29/18 | LasR LBD:BB0020 complex | Pseudomonas aeruginosa (strain UCBPP-PA14) | 2.2 | X-RAY DIFFRACTION | 100.0 |
6V7W | DNA BINDING PROTEIN/Viral protein | 12/09/19 | Crystal structure of LasR-Aqs1 complex from Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3 | 3 | X-RAY DIFFRACTION | 100.0 |
3IX8 | TRANSCRIPTION | 09/03/09 | LasR-TP3 complex | Pseudomonas aeruginosa | 1.8 | X-RAY DIFFRACTION | 100.0 |
6MWL | TRANSCRIPTION | 10/29/18 | LasR LBD:mBTL complex | Pseudomonas aeruginosa (strain UCBPP-PA14) | 1.5 | X-RAY DIFFRACTION | 100.0 |
6MWW | TRANSCRIPTION | 10/30/18 | LasR LBD:BB0126 complex | Pseudomonas aeruginosa (strain UCBPP-PA14) | 2.76 | X-RAY DIFFRACTION | 100.0 |
3IX4 | TRANSCRIPTION | 09/03/09 | LasR-TP1 complex | Pseudomonas aeruginosa | 1.8 | X-RAY DIFFRACTION | 100.0 |
3IX3 | TRANSCRIPTION | 09/03/09 | LasR-OC12 HSL complex | Pseudomonas aeruginosa | 1.4 | X-RAY DIFFRACTION | 100.0 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE | DB08324 | DrugBank | 5.1.4 | P25084 | Transcriptional activator protein LasR | 100.0 | 239 | 2.3e-135 |
Source 1 | |
Database | Victors : 4416 |
Category | |
Evidence |
ECO:0000015
mutant phenotype evidence
|
Host Organism | Dictyostelium discoideum |
Notes | |
Reference | 11867744 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 142 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001096 (1439 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_45960
Search term: lasR
Search term: transcriptional regulator LasR
|