Pseudomonas aeruginosa PAO1, PA0175 (cheR2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0175
Name
cheR2
Synonym: cheR2
Replicon chromosome
Genomic location 198688 - 199530 (- strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_248865.1
GI 15595373
Affymetrix PA0175_at
DNASU PaCD00006077
Entrez 882282
GenBank AAG03565.1
INSDC AAG03565.1
NCBI Locus Tag PA0175
protein_id(GenBank) gb|AAG03565.1|AE004455_6|gnl|PseudoCAP|PA0175
TIGR NTL03PA00176
UniParc UPI00001278BA
UniProtKB Acc Q9I6V7
UniProtKB ID CHER2_PSEAE
UniRef100 UniRef100_Q9I6V7
UniRef50 UniRef50_P07364
UniRef90 UniRef90_Q9I6V7

Product

Feature Type CDS
Coding Frame 1
Product Name
CheR2
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 5.86
Kyte-Doolittle Hydrophobicity Value -0.235
Molecular Weight (kDa) 32.0
Isoelectric Point (pI) 9.34

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 413 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000173 (379 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0175
Search term: cheR2
Search term: CheR2

Human Homologs

References

Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria.
Simms SA, Stock AM, Stock JB
J Biol Chem 1987 Jun 25;262(18):8537-43
PubMed ID: 3298235
Specificity of the CheR2 methyltransferase in Pseudomonas aeruginosa is directed by a C-terminal pentapeptide in the McpB chemoreceptor.
García-Fontana C, Corral Lugo A, Krell T
Sci Signal 2014 Apr 8;7(320):ra34
PubMed ID: 24714571