Pseudomonas aeruginosa LESB58, PALES_00181 (def)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa LESB58
Locus Tag
Replicon chromosome
Genomic location 21054 - 21560 (- strand)


RefSeq YP_002437629
GI 218888765
Entrez 7179973


Feature Type CDS
Coding Frame 1
Product Name
peptide deformylase
Product Name Confidence: Class 2
Evidence for Translation
Charge (pH 7) -8.13
Kyte-Doolittle Hydrophobicity Value -0.441
Molecular Weight (kDa) 19.4
Isoelectric Point (pI) 4.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1S17 HYDROLASE 01/05/04 Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors PSEUDOMONAS AERUGINOSA 1.95 X-RAY DIFFRACTION 99.4
1N5N HYDROLASE 11/06/02 Crystal Structure of Peptide Deformylase from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 99.4
1IX1 HYDROLASE 06/07/02 Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin PSEUDOMONAS AERUGINOSA 1.85 X-RAY DIFFRACTION 100.0
1LRY HYDROLASE 05/16/02 Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin PSEUDOMONAS AERUGINOSA 2.6 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
N-(2-Acetamido)Iminodiacetic Acid DB02810 DrugBank 5.1.4 Q9I7A8 Peptide deformylase 100.0 168 1.5e-91
2-(3,4-Dihydro-3-Oxo-2h-Benzo[B][1,4]Thiazin-2-Yl)-N-Hydroxyacetamide DB02036 DrugBank 5.1.4 Q9I7A8 Peptide deformylase 100.0 168 1.5e-91
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide DB04310 DrugBank 5.1.4 Q9I7A8 Peptide deformylase 100.0 168 1.5e-91

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 586 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000019 (554 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PALES_00181
Search term: def

Human Homologs


No references are associated with this feature.