Pseudomonas aeruginosa PAO1, PA3821 (secD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3821
Name
secD
Replicon chromosome
Genomic location 4277085 - 4278947 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252510.1
GI 15599016
Affymetrix PA3821_secD_at
Entrez 878279
GenBank AAG07208.1
INSDC AAG07208.1
NCBI Locus Tag PA3821
protein_id(GenBank) gb|AAG07208.1|AE004799_14|gnl|PseudoCAP|PA3821
TIGR NTL03PA03821
UniParc UPI00000C5B28
UniProtKB Acc Q9HXI1
UniProtKB ID SECD_PSEAE
UniRef100 UniRef100_Q9HXI1
UniRef50 UniRef50_Q9HXI1
UniRef90 UniRef90_Q9HXI1

Product

Feature Type CDS
Coding Frame 1
Product Name
secretion protein SecD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected using LC-MS/MS (67.67 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.75
Kyte-Doolittle Hydrophobicity Value 0.126
Molecular Weight (kDa) 67.7
Isoelectric Point (pI) 9.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001845 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3821
Search term: secD

Human Homologs

References

The secD locus of E. coli codes for two membrane proteins required for protein export.
Gardel C, Johnson K, Jacq A, Beckwith J
EMBO J 1990 Dec;9(12):4205-6
PubMed ID: 2249673
Genetic and molecular characterization of the Escherichia coli secD operon and its products.
Pogliano KJ, Beckwith J
J Bacteriol 1994 Feb;176(3):804-14
PubMed ID: 7507921
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344