Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4990
|
Name |
|
Replicon | chromosome |
Genomic location | 5606103 - 5606435 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_253677.1 |
GI | 15600183 |
Affymetrix | PA4990_at |
DNASU | PaCD00008155 |
Entrez | 880147 |
GenBank | AAG08375.1 |
INSDC | AAG08375.1 |
NCBI Locus Tag | PA4990 |
protein_id(GenBank) | gb|AAG08375.1|AE004912_1|gnl|PseudoCAP|PA4990 |
TIGR | NTL03PA04991 |
UniParc | UPI00000C5EB3 |
UniProtKB Acc | Q9HUH5 |
UniProtKB ID | MTDTR_PSEAE |
UniRef100 | UniRef100_Q9HUH5 |
UniRef50 | UniRef50_Q9HUH5 |
UniRef90 | UniRef90_Q9HUH5 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
SMR multidrug efflux transporter
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 3.21 |
Kyte-Doolittle Hydrophobicity Value | 1.444 |
Molecular Weight (kDa) | 11.5 |
Isoelectric Point (pI) | 9.86 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
Pseudomonas aeruginosa emrE | EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin. [PMID:12499164] | ARO:3004038 | protein homolog model | Perfect | 194.5 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 309 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004600 (529 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4990
Search term: SMR multidrug efflux transporter
|
The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.
Paulsen IT, Littlejohn TG, Rådström P, Sundström L, Sköld O, Swedberg G, Skurray RA
Antimicrob Agents Chemother 1993 Apr;37(4):761-8
PubMed ID: 8494372
|