Pseudomonas aeruginosa PAO1, PA5263 (argH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5263
Name
argH
Replicon chromosome
Genomic location 5924596 - 5925990 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253950.1
GI 15600456
Affymetrix PA5263_argH_at
Entrez 879636
GenBank AAG08648.1
INSDC AAA25721.1
NCBI Locus Tag PA5263
protein_id(GenBank) gb|AAG08648.1|AE004938_10|gnl|PseudoCAP|PA5263
TIGR NTL03PA05264
UniParc UPI0000125F04
UniProtKB Acc P50987
UniProtKB ID ARLY_PSEAE
UniRef100 UniRef100_P50987
UniRef50 UniRef50_P59618
UniRef90 UniRef90_P50987

Product

Feature Type CDS
Coding Frame 1
Product Name
argininosuccinate lyase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.47
Kyte-Doolittle Hydrophobicity Value -0.246
Molecular Weight (kDa) 51.6
Isoelectric Point (pI) 5.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 626 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004844 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5263
Search term: argH

Human Homologs

Ensembl 110, assembly GRCh38.p14
argininosuccinate lyase [Source:HGNC Symbol;Acc:HGNC:746]
E-value: 2.3e-104
Percent Identity: 44.2
Ensembl 110, assembly GRCh38.p14
argininosuccinate lyase [Source:HGNC Symbol;Acc:HGNC:746]
E-value: 2.3e-104
Percent Identity: 44.2

References

Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes.
Parsot C, Boyen A, Cohen GN, Glansdorff N
Gene 1988 Sep 7;68(2):275-83
PubMed ID: 2851495
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994