Pseudomonas aeruginosa PAO1, PA0072 (tagS1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0072
Name
tagS1
Replicon chromosome
Genomic location 85085 - 86284 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248762.1
GI 15595270
Affymetrix PA0072_at
DNASU PaCD00006031
Entrez 879189
GenBank AAG03462.1
INSDC AAG03462.1
NCBI Locus Tag PA0072
protein_id(GenBank) gb|AAG03462.1|AE004446_10|gnl|PseudoCAP|PA0072
TIGR NTL03PA00073
UniParc UPI00000C4F19
UniProtKB Acc Q9I760
UniProtKB ID Q9I760_PSEAE
UniRef100 UniRef100_Q9I760
UniRef50 UniRef50_Q9I760
UniRef90 UniRef90_Q9I760

Product

Feature Type CDS
Coding Frame 1
Product Name
TagS1
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 6.88
Kyte-Doolittle Hydrophobicity Value 0.430
Molecular Weight (kDa) 42.2
Isoelectric Point (pI) 9.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0334
Category Hcp secretion island-1 encoded type VI secretion system (H-T6SS)
Evidence ECO:0000305
curator inference used in manual assertion
Host Organism
Notes
Reference 16763151

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 35 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000071 (405 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0072
Search term: tagS1
Search term: TagS1

Human Homologs

References

A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.
Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD
Cell Host Microbe 2010 Jan 21;7(1):25-37
PubMed ID: 20114026
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology (Reading) 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433